Creating innovative bio-convergent technologies for better human life

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Therapeutic Biomaterials Engineering Laboratory
Ji Ho Park

Associate Professor

The research in the Therapeutic Biomaterials Engineering Laboratory (TBEL) in the Department of Bio and Brain Engineering at Korea Advanced Institute of Science and Technology (KAIST) is focused on the engineering of clinically relevant biocompatible materials that will exploit biological processes to treat dysregulation of complex diseases. The recent interests of the TBEL are in developing novel biosafe nanomaterials, understanding their interactions with biological microenvironments, and utilizing such nanotechnologies to enhance prevention and treatment of cancer. The long-term goal of the TBEL is to improve the function of living systems by designing materials, devices, and systems based on biological and non-biological components, or their hybrids. The TBEL is an interdisciplinary research lab spanning the interface of materials science, chemistry, biology and medicine.

Key Achievements

  • 1. "Cooperative Tumor Cell Membrane Targeted Phototherapy" Heegon Kim, Junsung Lee, Chanhee Oh, and Ji-Ho Park, Nature Communications (2017) 15880.
  • 2. “Liposome-Based Engineering of Cells to Package Hydrophobic Compounds in Membrane Vesicles for Tumor Penetration” Junsung Lee*, Jiyoung Kim*, Moonkyoung Jeong, Hyoungjin Lee, Unbyeol Goh, Hyaeyeong Kim, Byungji Kim, and Ji-Ho Park, Nano Lett. 15 (2015) 2938–2944 (*equal contribution).
  • 3. “Nanowire-Based Single Cell Endoscopy” Ji-Ho Park*, Ruoxue Yan*, Yeonho Choi, Chul-Joon Heo, Seung-Man Yang, Luke P. Lee, and Peidong Yang. Nature Nanotech. 7 (2012) 191-196 (*equal contribution).
  • 4. “Nanoparticles that Communicate In Vivo to Amplify Tumour Targeting” Geoffrey von Maltzahn, Ji-Ho Park, KevinY. Lin, Neetu Singh, Christian Schwöppe, Rolf Mesters, Wolfgang E. Berdel, Erkki Ruoslahti, Michael J. Sailor, and Sangeeta N. Bhatia, Nature Mater. 10 (2011) 545-552.
  • 5. “Cooperative Nanomaterial System to Sensitize, Target, and Treat Tumors” Ji-Ho Park, Geoffrey von Maltzahn, Mary Jue Xu, Valentina Fogal, Venkata Ramana Kotamraju, Erkki Ruoslahti, Sangeeta N. Bhatia, & Michael J. Sailor. Proc. Natl. Acad. Sci. USA. 107 (2010) 981-986.
  • 6. “Biodegradable Luminescent Porous Silicon Nanoparticles for in vivo Applications” Ji-Ho Park, Luo Gu, Geoffrey von Maltzahn, Erkki Ruoslahti, Sangeeta N. Bhatia, and Michael J. Sailor, Nature Mater. 8 (2009) 331-336.