Creating innovative bio-convergent technologies for better human life

Laboratory for Brain and Machine Intelligence
Sang Wan Lee

Assistant Professor



Engineering human intelligence by understanding how the brain learns


The key challenge for neuroscience and artificial intelligence


Machine learning algorithms have demonstrated an ability to succeed in various tasks, emerging as a general framework for problem solving. That being said, there is still a plenitude of brain’s advanced capabilities that the state-of-the-art algorithms fail to demonstrate. Recent neuroscience studies have provided evidence to suggest that the brain has multiple separate modes of learning and inference about the world, each of which can guide behavior in unique ways. After decades of study, we begin to understand how the brain’s subsystems interact with each other to ultimately produce coherent behavior.


The next challenge for both artificial intelligence and decision neuroscience is thus to understand the neural circuitry that is flexible enough to perform a wide range of tasks. It is becoming widely recognized that meta learning may be both the way the human brain actually works and the optimal design for an artificial intelligence that operates under constraints on performance, time, and energy


We aim to understand the nature of human intelligence on the deepest level, by interfacing neuroscience with artificial intelligence.


Recent studies have investigated neural mechanisms of different types of learning through a combination of various techniques measuring brain activity with computational learning models. However, little is known about how the brain determines which of these subsystems guides behavior at one moment in time. Our research interests are to develop a theory of how the brain, arguably at the higher level in the cognitive hierarchy of the prefrontal cortex, allocates control to multiple types of brain's subsystems, called meta-control. Specifically, we aim to investigate the neural and computational basis of the following functions: abstraction, intuition, inference, theory learning, goal-driven learning, and metacognitive learning.



We believe that understanding the brain opens the possibility for making scientific and technological advances.


We believe this understanding opens the possibility for making scientific and technological breakthroughs.


This theory will enable us to
(1-Neuroscience) understand the nature of human intelligence,
(2-Computational psychiatry) understand why and how a breakdown of these functions culminates in psychiatric disorders,
(3-Bioengineering) develop flexible and adaptive neuromorphic algorithms,


For more information, visit our website


Key Achievements
  • 1. D. Kim, G. Y. Park, J. P. O’Doherty*, and S. W. Lee*, “Task complexity interacts with state-space uncertainty in the arbitration process between model-based and model-free reinforcement-learning at both behavioral and neural levels,” Nature Communications, 10, 5738, 2019.
  • 2. J. H. Lee, B. Seymour, J. Z. Leibo, S. J. Ah, S. W. Lee*, “Towards high performance, memory efficient, and fast reinforcement learning - lessons from decision neuroscience,” Science Robotics, vol. 4, no. 26, 2019.
  • 3. S. Weissengruber+, S. W. Lee+, John P. O'Doherty, Christian C. Ruff, “Neurostimulation reveals context-dependent arbitration between model-based and model-free reinforcement learning,” Cerebral Cortex, 2019 (+: co-first authors).
  • 4. O. Choung, S. W. Lee*, and Y. Jeong*, “Exploring Feature Dimensions to Learn a New Policy in an Uninformed Reinforcement Learning Task,” Scientific Reports, vol. 7, no. 1, p. 17676, 2017.
  • 5. S. W. Lee*, T. Yi, J.-W. Jung, and Z. Bien, “Design of a Gait Phase Recognition System That Can Cope With EMG Electrode Location Variation,” IEEE Trans. Autom. Sci. Eng., vol. 14, no. 3, pp. 1429–1439, 2017.
  • 6. S. W. Lee*, J. P. O’Doherty, and S. Shimojo, “Neural Computations Mediating One-Shot Learning in the Human Brain.,” PLoS Biol., vol. 13, no. 4, p. e1002137, Apr. 2015. (Synopsis “How one-shot learning unfolds in the brain” by Weaver, J.)
  • 7. S. W. Lee*, S. Shimojo, and J. P. O’Doherty, “Neural Computations Underlying Arbitration between Model-Based and Model-free Learning,” Neuron, vol. 81, no. 3, pp. 687–699, Feb. 2014. (Front cover; preview “Decisions about decisions” by Yoshida, W. and Seymour, B.)
  • 8. S. W. Lee*, O. Prenzel, and Z. Bien, “Applying human learning principles to user-centered IoT systems,” IEEE Comput., vol. 46, no. 2, pp. 46–52, Feb. 2013. (cover feature)
  • 9. S. W. Lee, Y. S. Kim, and Z. Bien, “A Nonsupervised Learning Framework of Human Behavior Patterns Based on Sequential Actions,” IEEE Trans. Knowl. Data Eng., vol. 22, no. 4, pp. 479–492, Apr. 2010.
  • 10. S. W. Lee and Z. Bien, “Representation of a Fisher criterion function in a kernel feature space.,” IEEE Trans. Neural Networks, vol. 21, no. 2, pp. 333–339, Feb. 2010.