bioeng_admin
2010-12-20 21:45:44
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우리학과 조광현 교수님 연구실이 생명과학과 허원도 교수님 연구실과 공동으로 시스템생물학 연구를 통해, 오랫동안 수수께끼로 남아있던 심장질환 원인신호전달경로의 숨겨진 메커니즘을 규명해내었습니다. 연구결과는 Journal of Cell Science의 표지논문으로 선정되어 2010년 12월 13일자 온라인판(공식출판은 2011년 1월 1일자)에 게재되었습니다.
논문원본 사이트: http://jcs.biologists.org/cgi/content/abstract/124/1/82
저널커버 사이트: http://jcs.biologists.org/content/vol124/issue1/cover.dtl
(Cover: “A hidden incoherent regulation switch that coordinates the change in role of RCAN1 was elucidated through large-scale in silico simulations and single-cell live imaging. Kwang-Hyun Cho and colleagues found that this switch diverts negative regulation by RCAN1 to positive regulation, which leads to a biphasic response in a dose-dependent manner. See article by S.-Y. Shin et al. (pp. 82-90).”)
하이라이트뉴스 사이트: http://jcs.biologists.org/cgi/content/full/124/1/e106
(RCAN1 role switch explained. "The calcineurin-NFAT (nuclear factor of activated T cells) signalling pathway controls many physiological processes, including T-cell activation and cardiac cell growth. Regulator of calcineurin 1 (RCAN1) is a conserved regulator of this signalling network, but its functional role is hotly debated because, although it inhibits calcineurin-NFAT signalling in some experimental systems, it facilitates signalling in others. To resolve this debate, Kwang-Hyun Cho, Won Do Heo and colleagues (p. 82) have used a new approach in which they combine in silico simulations and single-cell live imaging experimentation. The authors' approach reveals a hidden incoherent regulation switch that is formed by cross-talk signals mediated through extracellular signal-regulated protein kinase and glycogen synthase kinase-3. This switch, they report, diverts negative regulation by RCAN1 to positive regulation, which leads to a dose-dependent biphasic response. Specifically, RCAN1 functions as an inhibitor when its levels are low, but as a facilitator when its levels are high. The authors conclude that the discovery of this incoherent regulation switch, which can induce apparently opposite responses depending on conditions, provides an explanation for the different roles of RCAN1 in calcineurin-NFAT signalling that have been suggested in previous studies." By Dr. Jane Bradbury)
논문원본 사이트: http://jcs.biologists.org/cgi/content/abstract/124/1/82
저널커버 사이트: http://jcs.biologists.org/content/vol124/issue1/cover.dtl
(Cover: “A hidden incoherent regulation switch that coordinates the change in role of RCAN1 was elucidated through large-scale in silico simulations and single-cell live imaging. Kwang-Hyun Cho and colleagues found that this switch diverts negative regulation by RCAN1 to positive regulation, which leads to a biphasic response in a dose-dependent manner. See article by S.-Y. Shin et al. (pp. 82-90).”)
하이라이트뉴스 사이트: http://jcs.biologists.org/cgi/content/full/124/1/e106
(RCAN1 role switch explained. "The calcineurin-NFAT (nuclear factor of activated T cells) signalling pathway controls many physiological processes, including T-cell activation and cardiac cell growth. Regulator of calcineurin 1 (RCAN1) is a conserved regulator of this signalling network, but its functional role is hotly debated because, although it inhibits calcineurin-NFAT signalling in some experimental systems, it facilitates signalling in others. To resolve this debate, Kwang-Hyun Cho, Won Do Heo and colleagues (p. 82) have used a new approach in which they combine in silico simulations and single-cell live imaging experimentation. The authors' approach reveals a hidden incoherent regulation switch that is formed by cross-talk signals mediated through extracellular signal-regulated protein kinase and glycogen synthase kinase-3. This switch, they report, diverts negative regulation by RCAN1 to positive regulation, which leads to a dose-dependent biphasic response. Specifically, RCAN1 functions as an inhibitor when its levels are low, but as a facilitator when its levels are high. The authors conclude that the discovery of this incoherent regulation switch, which can induce apparently opposite responses depending on conditions, provides an explanation for the different roles of RCAN1 in calcineurin-NFAT signalling that have been suggested in previous studies." By Dr. Jane Bradbury)
