bioeng_admin
2016-04-22 15:54:41
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- 제목: Computational Models and Applications of the Brain’s Navigation System: Grid cells and Place cells
- 연사: 곽지현 교수/ 고려대 뇌공학과
- 일시: 2016. 4. 27. (수) 오후 4:30 ~
- 장소: 정문술빌딩 219호
- 초록: Entorhino-hippocampal neural circuit is believed to be the brain region critical for spatial information processing, effectively functioning as the brain’s global positioning system (GPS). Place cells found in the hippocampus spike selectively when an animal is at one specific location within in an environment while grid cells found in the entorhinal cortex spike at multiple discrete locations, generating hexagonal grid patterns. It is well established that the hippocampal place cells receive afferent excitatory inputs directly from neurons in the entorhinal cortex (EC). However, how the hexagonal grid-like spike patterns of grid cells are translated into focal hippocampal place cell activity and how such spatial information is stored as memory in the entorhino-hippocampal circuit remains unclear. In this talk, the recent progress in computational models of grid cells and place cells will be presented followed by the results from our lab where we combine in vitro patch-clamp recordings with full-morphology NEURON model simulations. Our results demonstrate that the EC grid cell activities can be directly translated into hippocampal place cell activity and that long-term storage of spatial information could be achieved through hippocampal spike timing-dependent plasticity. Finally, we will introduce how such computational models of spatial navigation-specialized neurons could be used to develop a neuromorphic spatial navigation system.
문의: 백세범 교수 (4333)
