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Title : Diffuse Optical Tomography in Human Breast in-vivo

일시 : 2005년 8월12일 금요일 오후1:30

장소 : 정문술빌딩 220호

Author : Kijoon Lee, Ph.D,
Department of Physics and Astronomy
University of Pennsylvania

Abstract :

Diffuse Optical Tomography (DOT) is an emerging non-invasive functional imaging modality
which utilizes non-ionizing near-infrared light to probe deep tissue physiology.
Since the discovery of fortuitous spectral window in near-infrared in human tissue, in-vivo DOT has been developed
in various measurement schemes (CW, RF, and time-resolved) and geometries (remission, transmission, ring).


In this talk, we show how DOT is applied in human breast using multispectral CW transmission measurement
in slab geometry,
and how the reconstructed 3D chromophore concentration images can give us physiological information
that can be used for locating malignant tumors. Our current clinical instrument incorporates 6 different wavelength
with 45 different source positions, and a lens coupled CCD is used for CW transmission detection.
For reconstruction, nonlinear conjugate gradient algorithm is used along with FEM based forward solver,
where multispectral approach is used to solve for tissue chromophore concentrations and scattering amplitude directly.
Clinical result will be shown as well as phantom results, where contrasts in blood volume can tell us where malignant
tumor is. The tumor location matches well with the result from other modalities such as MRI and X-ray mammogram.