bioeng_admin
2005-07-05 21:09:10
0
183
세미나가 아래와 같이 개최하오니 많이 참석하여 주시기 바랍니다.
- 아 래 -
제목: MEMS-based Cell Manipulation System for Cellomics
연사: 김병규 박사 (Microsystem Research Center, KIST)
일시: 2005. 7. 5 (Tue) 오전 11:00-12:00
장소: 정문술빌딩 (E16) 219호
Among the various applications of microfabrication techniques for cellomics, this presentation focuses on single cell manipulation system and cell separation system which are widely required in cell biology. Two systems use AC electrokinetics-electroation and dielectrophoresis-, which is versatile and biologically noninvasive force and can be easily integrated with other manipulation technique. For single cell manipulation, an integrated cell processor is designed to carry out the routine and cumbersome, but essential process for biomanipulation. It includes microfludic channels for transporting, PPy valves for isolation, electrorotation for orientation, and aspiration through microhole for immobilization. Compact and cost effective fabrication process for the presented device was considered. The integrated functions are successfully demonstrated with mouse (B6CBA) embryo cells. For cell separation system, microfludics and dielctrophoreitic force are anlayzed to increase the sensitivity about cells. Based on analytic and numerical solution, 3D asymmetric microelectrode system for cell separation was designed. Using multi-physics simulation and experimental studies with biological samples, the efficiency of performance is verified and tested. The techniques developed in this paper will provide an automated platform for manipulating a single cell without losing the viability of the cell and can be used to separate the specific cells, like a stem cell, which is difficult to be discriminated in typical method. Based on cell biology and MEMS fabrication technology, micro-sized robot is feasible. Therefore, some interesting issues to construct muscle cell based micro robots will be delivered. In addition, current research activities related to cell migration and characterization in Bio-Nano Robotics Lab of Korea Institute of Science and Technology will be introduced.
- 아 래 -
제목: MEMS-based Cell Manipulation System for Cellomics
연사: 김병규 박사 (Microsystem Research Center, KIST)
일시: 2005. 7. 5 (Tue) 오전 11:00-12:00
장소: 정문술빌딩 (E16) 219호
Among the various applications of microfabrication techniques for cellomics, this presentation focuses on single cell manipulation system and cell separation system which are widely required in cell biology. Two systems use AC electrokinetics-electroation and dielectrophoresis-, which is versatile and biologically noninvasive force and can be easily integrated with other manipulation technique. For single cell manipulation, an integrated cell processor is designed to carry out the routine and cumbersome, but essential process for biomanipulation. It includes microfludic channels for transporting, PPy valves for isolation, electrorotation for orientation, and aspiration through microhole for immobilization. Compact and cost effective fabrication process for the presented device was considered. The integrated functions are successfully demonstrated with mouse (B6CBA) embryo cells. For cell separation system, microfludics and dielctrophoreitic force are anlayzed to increase the sensitivity about cells. Based on analytic and numerical solution, 3D asymmetric microelectrode system for cell separation was designed. Using multi-physics simulation and experimental studies with biological samples, the efficiency of performance is verified and tested. The techniques developed in this paper will provide an automated platform for manipulating a single cell without losing the viability of the cell and can be used to separate the specific cells, like a stem cell, which is difficult to be discriminated in typical method. Based on cell biology and MEMS fabrication technology, micro-sized robot is feasible. Therefore, some interesting issues to construct muscle cell based micro robots will be delivered. In addition, current research activities related to cell migration and characterization in Bio-Nano Robotics Lab of Korea Institute of Science and Technology will be introduced.
