|Prof. Luo Gu
|Department of Materials Science and Engineering, Johns Hopkins University
|2020. 12.4(금), 오전 10시~11:10
바이오및뇌공학과에서는 12/4(금), Healthcare/Brain+ 사업의 일환으로 아래와 같이 Webinar series를 개최합니다.
여러분들의 많은 관심과 참여 바랍니다!
1. 행사명 : Healthcare/Brain+ Webinar Series – Biomaterials for Engineering Mechanobiology
2. 일시 : 2020. 12.4(금), 오전 10시~11:10
3. webinar youtube link: https://youtu.be/CscCSDR4dl0
* 유투브 스트리밍시 기술적 오류가 발생하는 경우, 위 링크의 댓글에 새로운 웨비나 링크를 공지하오니, 10분이상 지연이 있을시 꼭 확인 부탁드립니다.
* 입장시 간단한 닉네임 또는 이름으로 접속.
* 등록은 필요하지 않습니다.
<Prof. Luo Gu>소개
Short bio: Prof Luo Gu is an assistant professor in the Department of Materials Science and Engineering at the Johns Hopkins University. His research focuses on understanding and engineering how cells sense and respond to the mechanical and biochemical cues from their microenvironment. In particular, his lab studies stem cell mechanotransduction for tissue regeneration, biomaterials-enabled immunotherapy for cancer and infectious diseases, and the delivery of genome editing tools. Dr. Gu received his BS in Chemistry from Peking University and his PhD in Chemistry with Specialization in Multiscale Biology from University of California San Diego. He joined Johns Hopkins in 2017 after completing his postdoctoral training at Harvard University.
Abstract: Directing Stem Cell Fate by Tuning Matrix Viscoelasticity
The microenvironment of cells is increasingly recognized to play critical roles in directing cell activity and fate. Biomaterials provide a means to engineer the cellular microenvironment both in vitro and in vivo, allowing us to study and manipulate various cell behaviors. Using biomaterials such as hydrogels as carriers for stem cell transplantation is a promising strategy to provide an optimal microenvironment to
the transplanted cells. Natural extracellular matrix (ECM) and living tissues are typically viscoelastic, exhibiting stress relaxation over a characteristic time-scale. We have developed viscoelastic hydrogels that can recapitulate the stress relaxation behavior of natural ECM and tissues. Using these hydrogels as cell culture scaffolds, we discovered that matrix stress relaxation plays an important role in regulating cell activity and differentiation. This finding in turn provided new design strategies for materials in tissue engineering.