Speaker : 최지현 책임연구원
Time : 2017. 03. 29 (수) PM 4:30~5:45
Venue : 양분순 빌딩 207호

Abstract: Cortical gamma oscillations (30 – 80 Hz) are crucial to consciousness, attention, perception, and memory formation, and failure in gamma regulation is a hallmark of neurological and psychiatric disease. Recent studies using optogenetics have shown that gamma oscillations are induced by selective activation of fast-spiking interneurons containing calcium-binding protein parvalbumin (PV) and the subcortical PV cells, particularly cortex projecting PV cells in basal forebrain (BF-PV cells), are responsible to trigger the cortical gamma band oscillation. However, the cortical regions in the gamma oscillation reign of BF-PV cells are not known. Here, we combined the optogenetic interrogation with high density EEG in freely moving mice to detmine the spatio-frequency characteristics of cortical gamma band oscillation driven by BF-PV cells. We found that gamma band oscillation of BF-PV cells induced cortical gamma oscillation in the frontal cortex, whereas slow oscillation of these neurons induced diffusive and variant cortical activation mostly in the centro-parietal cortex. We further applied pulse train sound locking to the optogenetic stimulation. An in-phase activation of BF-PV cells lead more phasic response to the auditory sound, whereas out-of-phase activation suppressed the auditory evoked frontal responses. Thus, these findings indicate that BF-PV cells generate the frontal gamma oscillation and may be involved in their functional role.