O Speaker: Dr. Thomas McHugh

O Affiliation: RIKEN Center for Brain Science, Lab for Circuit & Behavioral Physiology

O Date: April 09, 2025

O Start Time: 4:00 PM

ABSTRACT:

The hippocampus plays a crucial role in episodic memory; the who, what, where memories that define our lives. In the rodent, its well-defined anatomy and physiology make the structure an ideal model system; amenable to circuit manipulations and observations designed to test hypotheses concerning how memories are formed, consolidated and used. Here I will present our recent work in mice which combines anatomical characterization, genetic intervention and in vivo recording to address how non-cononical hippocampal output can influence neuromodulation, circuit dynamics and memory. Specifically, I will focus on the CA2 region and how its activity can impact both local and distal circuits, including our identification and characterization of a novel descending glutamatergic projection from CA2 pyramidal cells to PV+ neurons in the medial septum that can regulate cholinergic tone and bidirectionally modify both the encoding and consolidation of hippocampal dependent memory.

* The seminar will be held offline and online[https://kaist.zoom.us/j/86770940131] simultaneously.

* Closed Caption interpretation service (English) available online (service provided by Zoom)